Which of the following is a common issue in individuals with PKU?

Individuals with Phenylketonuria (PKU) often experience intellectual disability due to the body’s inability to properly metabolize phenylalanine, an amino acid found in many protein-containing foods. If PKU is not managed through a strict diet low in phenylalanine, elevated levels of this substance can build up in the blood, leading to damage in brain development and function. This neurotoxicity can significantly impact cognitive abilities, resulting in varying degrees of intellectual disability.

While some of the other options might seem relevant, none are as directly associated with PKU as intellectual disability. For instance, impaired vision, catastrophic health events, and physical deformities are not common or intrinsic issues found in most individuals with PKU. The central risk associated with untreated PKU primarily revolves around cognitive outcomes, making intellectual disability the standout concern for individuals with the condition.